PharmaKB logo
Company Reports
Company Reports
Drug Reports
Drug Reports
Disease Reports
Disease Reports
Sets
Sets
Favorites
Favorites
Log in
Log in
AboutPricing
Drug ReportsMethylthioninium chloride
Methylene blue
Methylene Blue, Provayblue (methylene blue) is a small molecule pharmaceutical. Methylene blue was first approved as Provayblue on 2016-04-08. It is used to treat cyanosis, herpes simplex, lithiasis, methemoglobinemia, and poisoning amongst others in the USA.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Plot placeholder
Mock data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
arthcal 1% methylene blueC2002632025-03-13
hyophenunapproved drug other2017-01-05
mb capsunapproved drug other2025-02-25
methylene blueANDA2025-03-06
methylene blue injunapproved drug other2023-08-09
phosphasalunapproved drug other2017-01-24
provayblueNew Drug Application2024-12-19
urelleunapproved drug other2015-01-13
uretron d/sunapproved drug other2025-02-28
uribelunapproved drug other2017-01-24
Show 11 more
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration
Code
METHYLENE BLUE, PROVAYBLUE, PROVEPHARM SAS
2027-01-08M-303
Patent Expiration
No data
ATC Codes
V: Various drug classes in atc
— V03: All other therapeutic products
— V03A: All other therapeutic products
— V03AB: Antidotes
— V03AB17: Methylthioninium chloride
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CG: Gastric secretion test diagnostic agents
— V04CG05: Methylthioninium chloride
HCPCS
Code
Description
Q9968
Injection, non-radioactive, non-contrast, visualization adjunct (e.g., methylene blue, isosulfan blue), 1 mg
Clinical
Clinical Trials
334 clinical trials
View more details
Plot placeholder
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MethemoglobinemiaD008708—D74———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameMethylene blue
INNmethylthioninium chloride
Description
Methylene blue is an organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor, an acid-base indicator, a fluorochrome, an antidepressant, a cardioprotective agent, an EC 3.1.1.8 (cholinesterase) inhibitor, a histological dye, an EC 4.6.1.2 (guanylate cyclase) inhibitor, an antioxidant, an antimicrobial agent, a neuroprotective agent, a physical tracer and an antimalarial. It contains a 3,7-bis(dimethylamino)phenothiazin-5-ium.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)c1ccc2nc3ccc(=[N+](C)C)cc-3sc2c1.O.O.O.[Cl-]
Identifiers
PDB—
CAS-ID61-73-4
RxCUI—
ChEMBL IDCHEMBL550495
ChEBI ID—
PubChem CID6099
DrugBankDB09241
UNII ID8NAP7826UB (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Plot placeholder
Mock data
Subscribe for the real data
Additional graphs summarizing 77,445 documents
View more details
Safety
Black-box Warning
Black-box warning for: Methylene blue, Methylene blue inj, Provayblue
Adverse Events
Top Adverse Reactions
Plot placeholder
Mock data
Subscribe for the real data
1,395 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use